MixWild & MixRegLS - programs for intensive longitudinal data

The MixWild program extends MixRegLS in several important ways.  MixWild allows for multiple random location effects (e.g., intercepts and slopes), in addition to a random scale effect.  These random subject effects (multiple location and one scale) can then be used as predictors in a Stage 2 model of a subject-level outcome that could be continuous (multiple regression) or discrete (binary/ordinal logistic regression).  Also, MixWild includes a graphical user interface (GUI) to facilitate program use.     

MixWild program

MixWild user's guide and example dataset

MixWild presentation file 1MixWild presentation file 2

MixRegLS program - this zip file contains the MIXREGLS program, manual, and several examples

Some publications describing mixed-effects location scale models

  • Hedeker D, Mermelstein RJ, & Demirtas H. (2008).  An application of a mixed-effects location scale model for analysis of Ecological Momentary Assessment (EMA) data. Biometrics, 64: 627-634. pdf file   supplemental materials

  • Hedeker D, Demirtas H, & Mermelstein RJ. (2009).  A mixed ordinal location scale model for analysis of ecological momentary assessment (EMA) data. Statistics and Its Interface, 2:391-402. pdf file

  • Hedeker D, Mermelstein RJ, & Demirtas H. (2012).  Modeling between- and within-subject variance in Ecological Momentary Assessment (EMA) data using mixed-effects location scale models. Statistics in Medicine, 31:3328-3336.  pdf file

  • Hedeker D & Mermelstein RJ (2012).  Mood changes associated with smoking in adolescents: An application of a mixed-effects location scale model for longitudinal Ecological Momentary Assessment (EMA) data. In G. R. Hancock & J. Harring (Eds.), Advances in Longitudinal Methods in the Social and Behavioral Sciences (pp. 59-79). Information Age Publishing, Charlotte, NC.  pdf file

  •  Li X & Hedeker, D. (2012). A three-level mixed-effects location scale model with an application to ecological momentary assessment (EMA) data. Statistics in Medicine, 31:3192-3210.  pdf file   supplemental materials

  • Pugach O, Hedeker D, Richmond MJ, Sokolovsky A, & Mermelstein, RJ (2014).  Modeling mood variation and covariation among adolescent smokers: Application of a bivariate location-scale mixed-effects model. Nicotine and Tobacco Research, 16, Supplement 2, S151-S158.  pdf file

  • Pugach O, Hedeker D, & Mermelstein RJ (2014).  A bivariate mixed-effects location-scale model with application to ecological momentary assessment (EMA) data.  Health Services and Outcomes Research Methodolology, 14(4):194-212.  pdf file

  • Kapur K, Li X, Blood EA, & Hedeker D (2015).  Bayesian mixed-effects location and scale models for multivariate longitudinal outcomes: An application to ecological momentary assessment data. Statistics in Medicine, 34:2312-2324.  pdf file

  • Hedeker D, Mermelstein RJ, Demirtas H, & Berbaum ML (2016).  A mixed-effects location-scale model for ordinal questionnaire data. Health Services and Outcomes Research Methodology, 16(3):117-131.  pdf file

  • Lin X, Mermelstein RJ, & Hedeker D (2018).  A three level Bayesian mixed effects location scale model with an application to Ecological Momentary Assessment (EMA) data.  Statistics in Medicine, 37: 2108–2119.  pdf file  supplemental materials

  • Lin X, Mermelstein RJ, & Hedeker D (2018, epub).  A shared parameter location scale mixed efect model for EMA data subject to informative missing.  Health Services and Outcomes Research Methodology.  pdf file

  • Courvoisier, D., Walls, T.A., Cheval, B., & Hedeker, D. (2018, epub).  A mixed-effects location scale model for time-to-event data: A smoking behavior application. Addictive Behaviors.  pdf file